Bioss Inc.'s SARS-CoV-2 Nucleocapsid monoclonal Antibody is a Mouse monoclonal antibody. The SARS-CoV-2 Nucleocapsid monoclonal Antibody was generated using N as the antigen. It reacts with 2019-nCoV, Corona Virus, Coronavirus, COVID-19, SARS-CoV-2, and Virus. This antibody has been shown to work in applications such as: EIA, Immunoassay, and ELISA.
Description
Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein. Coronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is a most abundant protein of coronavirus. During virion assembly, N protein binds to viral RNA and leads to formation of the helical nucleocapsid. Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. Because of the conservation of N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool